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Studies have demonstrated that 4% niacinamide can significantly reduce melasma severity ( Navarrete-Sols et al., Dermatology Research and Practice, 2011 ), improve moisture retention, and enhance overall texture ( Boo, 2021 )

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an extended version of this table, detailing pertinent experimental conditions, is shown in Table S4)

Stress can contribute to poor nutrition or impairing digestion and absorption over time, while alcohol abuse interferes with absorption in the digestive system and damages the stomach lining ( 5 ) ( 6 )

The Kennedy pathway de novo synthesis of phosphatidylethanolamine and phosphatidylcholine

Western blotting Western blotting was performed as previously described 6