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Still, high doses could have some side effects, like dizziness, headache, anxiety, nausea, and vomiting
Bibiloni, R

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Upon IB degradation, NF-B is released and translocates into the nucleus, where it recruits p300, which in complex with cAMP response element-binding protein acetylates RelA/p65, thereby activating NF-B transcription and enhancing the expression of downstream pro-inflammatory genes (Lawrence 2009)

The limited volume that the nasal cavity can accommodate, approximately 100-200 microliters per nostril without runoff, means that higher concentrations deliver more peptide per spray
Pregnant or lactating women should consult their qualified healthcare provider prior to use
