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Behavioral testing was followed by biochemical analyses on colon, faces, serum, cerebellum, and prefrontal cortex, assessing tryptophan metabolites, serotonin (5-HT) pathway intermediates, neurotransmitters (GABA, glutamate, dopamine, acetylcholine) via UPLC, UPLC-TQD, and ELISA, alongside gut microbiota profiling through 16S r RNA sequencing

In the same animal model an improvement of mitochondrial respiration and muscle function has been also observed [51]

Ferris HA, Perry RJ, Moreira GV, Shulman GI, Horton JD, Kahn CR

Multiple facial trichilemmomas, multiple oral papules, and palmoplantar hyperkeratosis form the triad

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