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Rigorous evaluation of RNA-small molecule binding by BIVID-MaP may help reassess existing compounds and optimize drug discovery for individuals with specific genetic variants

With respect to artifacts, a comparison of the ligands bound when At GSTF2 was recovered from being expressed transiently in Nicotiana with those retained by the enzyme when solvent extracts from the identical plant tissue were passed over the immobilized protein, strongly suggested that the glutathionylated lignanamides ( 5, 6, 7 ) were artifacts formed during extraction

2021;53:e14147

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Furthermore, the levels of GPx1 have been observed to exhibit a direct correlation with the progression to advanced metastatic cancer, underscoring its potential role in cancer biology (179, 180)

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