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ROS production from XOR is implicated in several pathological conditions, including heart failure 75

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Moreover, previous studies demonstrate that IGF promotes mitochondrial biogenesis and turnover in cancer cells by inducing peroxisome proliferator-activated receptor coactivator 1 (PGC-1), PGC-1-related coactivator, nuclear factor-erythroid-derived 2-like 2 (NFE2L2/NRF2), and the mitophagy mediator BNIP3 [63]

Berberich ME, Beaulieu JJ, Hamilton TL, Waldo S, Buffam I (2019) Spatial variability of sediment methane production and methanogen communities within a eutrophic reservoir: importance oforganic matter source and quantity
