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Detailed stages of the cycle: CPT-1 (outer mitochondrial membrane): Acyl-CoA + L-carnitine Acyl-carnitine + CoA-SH Rate limiting enzyme Inhibited by malonyl-CoA Isoforms: CPT-1A (liver), CPT-1B (muscle), CPT-1C (brain) CACT (translocase): Transport of acylcarnitine into the matrix Antiport with free carnitine The only transporter for acylcarnitines CPT-2 (inner mitochondrial membrane): Acyl-carnitine + CoA-SH Acyl-CoA + L-carnitine Regeneration of acyl-CoA in the matrix Not regulated by malonyl-CoA -oxidation (matrix): Cyclic shortening of the acyl chain Products: acetyl-CoA, FADH2, NADH CPT-1 regulation Research on Cell Cultures L-carnitine tested on various cell types: Cardiomyocytes: main source of energy from -oxidation Myotubes (C2C12): skeletal muscle metabolism Hepatocytes: ketogenesis and gluconeogenesis Adipocytes: lipolysis and lipid metabolism Cancer cells: Warburg metabolism vs

De werking van levocarnitine is door de combinatie van carnitine en acetyl zeer waardevol voor het lichaam

PMID: 28699143 4 Organic anion transporters in remote sensing and organ crosstalk

AFTER 2.5MG DOSE, THE DOSAGE PER INJECTION INCREASES GRADUALLY TO 5MG, THEN 7.5MG ETC TIRZEPATIDE 7.5MG IS THE RECOMMENDED MAINTENAINCE DOSE

Large-sample and well-designed studies have identified a deletion of exon 2 of the trimethyllysine hydroxylase epsilon (TMLHE) gene and linked this deletion with autism spectrum disorder (ASD)

doi: 10.1249/MSS.0b013e3181eb6265, 77