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These considerations show that there is a dire need to understand the correlation between seminal plasma oxidative stress and sperm DNA damage and for the development of new diagnostic methods

However, the precise molecular mechanisms through which these metabolites modulate OS remain only partially understood

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Importantly, unlike the strictly regulated ALOX enzymes, POR is ubiquitously expressed, suggesting that POR might be a constitutive fashion for lipid peroxidation

Elevated ROS levels could also provide the cause for early elevation of antiangiogenic or decrease in angiogenic factors at a time when the placenta needs more vascular development

The Lancet Psychiatry, 3(8), 760773