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This is particularly significant for obesity research, as NNMT levels are frequently elevated in the adipose tissue of obese individuals

Loss of myostatin (GDF8) function increases osteogenic differentiation of bone marrow-derived mesenchymal stem cells but the osteogenic effect is ablated with unloading

doi: 10.1016/j.metop.2021.100123, PMID: [DOI] [PMC free article] [PubMed] [Google Scholar] 8

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I often wonder if one of the mechanisms behind this is the depletion of selenium