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Intriguingly, this effect was observed exclusively in female mice, a result that was unexpected because females generally exhibit a more proficient defense against ROS than males [9]

The plasma TAC/MDA ratio was calculated as an index of oxidative status

Buell JS, Dawson-Hughes B

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Ferroptosis inducers can promote the accumulation of intracellular iron and lipid peroxides, activating the ferroptosis pathway and leading to tumor cell death