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These second messengers, particularly cAMP, may activate protein kinases, enzymes considered responsible for phosphorylating target proteins

10.1016/j.cell.2017.10.036 23

PSC is one of many causes of bile duct damage and narrowing that are broadly termed cholangiopathies

If your protocol has an inflammation component, that extra axis of coverage can make the difference between adequate and thorough inflammatory control

This article was reviewed and minor updates were made in February 2026.

A non-parametric KruskalWallis test was used to assess significance among groups, due to the non-normal distribution of the data, and using Wolfram Mathematica 11.3 (Wolfram Alpha LLC) for analyses