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Vaccine 28(19):33123317 Limaye SA, Haddad RI, Cilli F, Sonis ST, Colevas AD, Brennan MT, Hu KS, Murphy BA (2013) Phase 1b, multicenter, single blinded, placebo-controlled, sequential dose escalation study to assess the safety and tolerability of topically applied AG013 in subjects with locally advanced head and neck cancer receiving induction chemotherapy

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In another study, chlorophyllin treatment has been reported to cause cell cycle arrest in HCT116 colon cancer cells through the increased expression of E2F1 and E2F4 transcription factors inhibiting the G1/S checkpoint step, which is an important cell cycle checkpoint (Chimploy et al