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Importance of long-term follow-up in evaluating treatment regimens for adults with acute lymphoblastic leukemia

38 This pain commonly presents as spontaneous burning sensations in the feet, and patients may also report positive sensory symptoms such as brush-evoked allodynia (pain from normally non-painful stimuli) and paresthesias, which are often accompanied by sensory loss, leading patients to describe the paradox of their feet being continuously painful yet insensate to touch

Concentration gradient drives the diffusion rate, so higher initial concentrations at the absorption site generally produce faster uptake

PMID 12086562

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Moreover, iron deficiency in later stages of development, such as during childhood, may be associated with impaired cognitive development (see the article on Iron)