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other cytokines such IL-21 could also be important for this process Continuous B-cell activation as a result of the autoimmune response and subtle deficiencies in the control of nuclear factor B activation might underlie increased lymphomagenesis associated with pSS IL-12 is a central cytokine in pSS pathogenesis, promoting activation of the type II IFN system via both the innate (natural killer cells) and the adaptive (type 1 T-helper cells) immune systems Epithelial cells are major players in pSS pathogenesis, not only as targets of disease, but also as drivers of the disease process that promote overactivation of the immune system Many similarities exist between systemic lupus erythematosus and pSS pathogenesis

The neuroprotective/neurorescue activites of propargylamines, including propargylamine itself, also involve alterations in APP processing

R., Almutawa, F., Lim, H

Dimethyl fumarate: a review of preclinical efficacy in models of neurodegenerative diseases

Through the Fenton reaction, H 2 O 2 interacts with iron ions to produce highly reactive hydroxyl radicals ( OH), which can damage biomolecules including proteins, lipids, and DNA, thereby impairing cellular functions and leading to cell death [114]