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[DOI] [PMC free article] [PubMed] [Google Scholar] 63.Wilcock G.K., Gauthier S., Frisoni G.B., Jia J., Hardlund J.H., Moebius H.J., Bentham P., Kook K.A., Schelter B.O., Wischik D.J., et al

the morning hypofibrinolytic and hypercoagulable state, in combination with increased PAI-1 levels, may contribute to less effective tPA treatment in the morning