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Description
28,29,30 NOX-mediated ROS broadly and specifically regulate various redox-sensitive signaling pathways involved in cancer progression via stimulating oncogenes, such as Src and Ras, and inactivating tumor suppressor proteins, such as TP53 and PTEN

Han D, Canali R, Garcia J, Aguilera R, Gallaher TK, and Cadenas E

It also promotes reactive oxygen species (ROS)mediated apoptosis, selectively harming cancer cells while sparing normal cells

Altering its levels without a clear medical indication could potentially disrupt these vital processes

R.ChenH.ChipotC.KohlmeyerA.et al (2024)

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