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Many ocular manifestations of glaucoma (IOP changes, calcium overloads, reactive gliosis, cytokine release, microvascular dysfunction, actin upregulation, fibronectin secretion and RGC apoptosis) can be mimicked pharmacologically by stimulating TRPV4 channels in RGCs, glial, endothelial, ciliary body and trabecular meshwork cells (27, 111, 127, 133)

doi: 10.1016/j.gde.2023.102114 30 ZhangYZhangHChangDGuoFPanHYangY

Sterility Maintaining sterility is important when administering injections

Gut microbiota biotransform primary BAs into secondary BAs through enzymatic modifications, predominantly via deconjugation and dehydroxylation

Protective effect of Annona muricata Linn fruit pulp lyophilized powder against paracetamol-induced redox imbalance and hepatotoxicity in rats