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Hormones Hormone imbalances, pregnancy, breastfeeding and certain medications such as the oral contraceptive pill can result in melasma which is an overproduction of melanin at both superficial and deep layers of the skin
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In the last stage of their development (stage IV), the melanosomes are fully melanized and are transported to surrounding keratinocytes by elements of the cytoskeletal system
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Effect of intraventricular injection of 1-methyl-4-phenylpyridinium: protection by acetyl-L-carnitine Hum Exp Toxicol 1995
