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Oral vitamin B12 is generally safe to take at recommended doses

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There are a few common, mild side effects associated with B12 shots, including: Mild diarrhea, itching, nausea and vomiting, dizziness, headaches, and hot flashes Redness or swelling at the injection site Temporary soreness at injection site Serious side effects are rare but require immediate medical attention

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Refrigeration is commonly used for long-term storage of lyophilized compounds