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In addition, resveratrol has been identified to activate the Sirt3-Foxo3a-PINK1-PARKIN-Mitochondrial fusion-fission-mitophagy signaling network, reducing ROS, and preserving GSH and reducing the aging phenotype (122)

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In spite of significant efforts in cardiac tissue engineering, there is still a lack of conclusive materials, methodologies, and cellular resources, leading to ongoing research, particularly because in vivo studies have been limited

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