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Excessive NAM depletion directly reduces the substrate supply for NAD+ synthesis, leading to decreased intracellular NAD+ levels
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A 41-year-old woman was referred for headaches and numbness in the extremities
In light of the fact that these three anti-CD38 show similar safety and efficacy profiles, it is hypothesized that ADCC is the main mechanism of action of these antibodies in MM [41-42]
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The Nuclear Receptor LXR Limits Bacterial Infection of Host Macrophages through a Mechanism that Impacts Cellular NAD Metabolism
