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Here, we propose the hypothesis that a dysfunction during development in either NMDAR-mediated signaling, neuroimmune regulation, mitochondria function could initiate vicious circles centered on redox dysregulation/OxS, leading to persistent anomalies of PV neurons and oligodendrocytes and ultimately to neural synchronization, cognitive, emotional, social and sensory deficits characteristic of schizophrenia (Fig

Dark bars along the x-axis indicate the animals dark cycle

Intracellularly, the LOX isoforms are primarily found in the cytoplasm in their inactive form and upon activation, it will translocate to the nucleus or membrane (plasma, intracellular) (Rdmark and Samuelsson, 2009)

Intermittent hypoxia leads to functional reorganization of mitochondria and affects cellular bioenergetics in marine molluscs

Zakiullah, Ahmadullah, Khisroon M, Saeed M, Khan A, Khuda F, et al

By screening a number of reductants, they discovered that Tris (3-sulfonatophenyl) phosphine (TSPP) can selectively remove TNB-caps without attacking the interchain disulfides