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Proc Natl Acad Sci 94:75317536

147 Although the susceptibility of transplanted cellular constructs to the typical progression of PD pathology is still unclear, dopaminergic neurons from tissue grafts can survive up to 24 years in vivo despite ongoing degeneration of the native dopaminergic system

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In PD, this process has dual consequences: (1) autonomous neuronal death, where GSDMD pores disrupt mitochondrial and ER membranes in dopaminergic neurons, inducing calcium overload and energy depletion, and (2) neuroinflammatory propagation, where IL-1 activates microglia and astrocytes, driving further production of TNF-, nitric oxide (NO), and ROS (O 2 - ), which activate NLRP3 in adjacent neurons [50]

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Moreover, SIRT1 protects mitochondrial function of HCC cells by suppressing the expression of hypoxia-induced factor-1 alpha expression and also promotes stem-cell like features in HCC cells [187]