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Description
The NICE Guideline NG239 (2024) and the AAFP clinical review both support this approach

Vitamin B12 deficiency Vitamin B12 is an essential water-soluble nutrient also known as cobalamin
AOD9604 regulates fat metabolism by especially targeting areas having a high amount of fat deposition

NNMT (nicotinamide N-methyltransferase) catalyses transfer of a methyl group from S-adenosylmethionine to nicotinamide

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Thus all of the DNA synthetic effects of B 12 deficiency, including the megaloblastic anemia of pernicious anemia, resolve if sufficient dietary folate is present
