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Among those that make the daily functioning of patients with CHC particularly difficult are problems with memory and concentration, depression, fatigue, and cognitive disorders, which are believed to be immune-mediated, but a direct effect of cytotoxic HCV on the nervous system is also suspected [5]

7,8-dihydroxyflavone, a small-molecule TrkB agonist, reverses memory deficits and BACE1 elevation in a mouse model of Alzheimers disease

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Nevertheless, the primary obstacle impeding further advance and widespread adoption of fat grafting lies in the unpredictable resorption rates and low survival rates of the transplanted fat [197]

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