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Alle diese unterschiedlich zustande kommenden Mangelzustnde fhren zu Vernderungen des in allen biologischen Rumen lebender Systeme vorliegenden negativen Redoxpotentials und ber Entgleisungen des "Redoxverschiebe-Systems" zu Enzymstrungen, vor allem in antioxidativen Enzymen und Reparaturenzymen, zur Zellstoffwechsel-Entgleisung, zu Mutationen, zur malignen Transformation oder auch zur Zellnekrose.All of these deficiency states, which come about differently, lead to changes in the negative redox potential present in all biological spaces of living systems and to derailment of the "redox displacement system" to enzyme disorders, especially in antioxidative enzymes and repair enzymes, to derail cell metabolism, to mutations, to malignant transformation or to cell necrosis

ERS activates a series of cascading reaction pathways, regulating the formation of intracellular iron ions and ROS through iron metabolism, Xc-/GPX4 system (Zhao et al., 2021), lipid metabolism (Tak et al., 2022), and other ferroptosis pathways such as p62-Keap1-NRF2, p53-SAT1-ALOX15, ATG5-ATG7-NCOA4, and glutaminolysis (Lane et al., 2018), playing a dual role in ferroptosis

Acidity-triggered charge-convertible nanoparticles that can cause bacterium-specific aggregation in situ to enhance photothermal ablation of focal infection

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Saha, S.R

Fatema K, et al