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A new progeroid syndrome reveals that genotoxic stress suppresses the somatotroph axis

Metabolites of GRP produced by microbiota can be categorized into the following three groups: (i) GLs such as glucoerucin, (ii) ITCs such as SFN and erucin, and (iii) ITC-nitriles such as SFN-nitrile and erucin-nitrile

By suppressing the expression of anterior pharynx-defective-1alpha and -1beta and inhibiting the aggregation of beta-amyloid protein, magnesium ions inhibit the cognitive decline of amyloid precursor protein/presenilin 1 transgenic mice

Concurrently, ER can induce autophagy independently of classical pathways (mTOR, PI3KCIII, MAPK) via regulators such as BAG3, ATG7, and WIPI, while ER modulates autophagy in a context-dependent manner, influencing autolysosome formation, cyclin degradation, HIF function, and interacting with autophagy-related proteins (ULK1, BECN1, LC3B, ATG16L1, p62) and the NLRP6 inflammasome

G.KoutedakisY.KouretasD

Hypoxia-induced proliferation in mesenchymal stem cells and angiotensin II-mediated PI3K/AKT pathway