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Optimal dosing varies based on individual factors including body weight, body composition goals, and metabolic responsiveness

One prime example is the discovery of the nutrient sensing mechanism for cholesterol, which led to the development of life-saving statin drugs (and the Nobel Prize)

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doi: 10.1039/C7FO00659D

[DOI] [PubMed] [Google Scholar] 41.Sudeep H.V., Venkatakrishna K., Patel D., Shyamprasad K

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