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First, the inner mitochondrial membrane (IMM) must be physically intact so that protons can only re-enter the matrix of the mitochondrion by a process coupled to ATP synthesis

Abnormal growth patterns and adult short stature in 115 long-term survivors of childhood leukemia
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It eventually finds its way back to the ocean via the water table, and by percolating through the rocks and underground material

however, the coexistence of both forms is possible
