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Ishihara S, Kawashima K, Fukuba N, Tada Y, Kotani S, Mishima Y, et al
[DOI] [PubMed] [Google Scholar] 12.Dallongeville J, Fruchart JC, Auwerx J
Combined treatment with IC261 and APR-017 resulted in a remarkable reduction in cell viability and a significant increase in ROS level when compared to the control or single treatment groups (Fig

type 2 diabetes), or obesity-related comorbidities may need standard or higher doses to get robust benefits

Toruner M, Loftus EV Jr, Harmsen WS, Zinsmeister AR, Orenstein R, Sandborn WJ, Colombel JF, Egan LJ (2008) Risk factors for opportunistic infections in patients with inflammatory bowel disease
However, a high level of ROS inhibits the occurrence and development of tumors by inducing apoptosis of tumor cells because of their toxic effects [40]