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Finally, knockdown of ACLY or TMLHE alone increased sensitivity to DNA-damaging agents, and this effect was additive on double knockdown (Fig

Besides eGFR, additional variables associated with kidney function including plasma urea 29 , the uremic toxin p -cresol 30 or markers of kidney function decline (i.e., serum albumin 29 ), were among those affecting model outcomes the most

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These findings suggest potential clinical roles for ALC in patient groups underserved by current antidepressant options, including those with poor tolerability to standard antidepressants or with late-onset depressive syndromes