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Hayano, T

Science 253:12801283 Ohta K, Makinen KK, Loesche WJ (1986) Purification and characterization of an enzyme produced by Treponema denticola capable of hydrolyzing synthetic trypsin substrates

Consequently, significant accumulation of nanoparticles occurs in organs such as the spleen and liver, resulting in nonspecific distribution of nanotherapeutic drugs to healthy organs
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