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Months 3-6: Approaching the Maintenance Phase What the trials documented: By around month four (week 17), the REDEFINE protocol reached the 2.4 mg maintenance dose, and weight loss continued to accrue beyond that point through the 68-week primary endpoint (Aronne et al., 2025)

Its primary function is in tissue repair: it promotes actin polymerization (required for cell movement), upregulates anti-inflammatory proteins, and stimulates the migration of keratinocytes and endothelial cells that are needed to close and repair damaged tissue

These reactions are central to cellular physiology, supporting vital functions such as metabolism, cell signaling, energy production, and detoxification

Immunity 34 , 237246 (2011)

doi:10.4161/epi.28711

Some patients require a short course to correct deficiency, while others may benefit from maintenance injections over time
