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Months 3-6: Approaching the Maintenance Phase What the trials documented: By around month four (week 17), the REDEFINE protocol reached the 2.4 mg maintenance dose, and weight loss continued to accrue beyond that point through the 68-week primary endpoint (Aronne et al., 2025)

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Its primary function is in tissue repair: it promotes actin polymerization (required for cell movement), upregulates anti-inflammatory proteins, and stimulates the migration of keratinocytes and endothelial cells that are needed to close and repair damaged tissue

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These reactions are central to cellular physiology, supporting vital functions such as metabolism, cell signaling, energy production, and detoxification

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Immunity 34 , 237246 (2011)

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doi:10.4161/epi.28711

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Some patients require a short course to correct deficiency, while others may benefit from maintenance injections over time

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