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The consumption of red peppers in kochujang has been shown to improve inflammation in rats with dextran sulfate sodium-induced colitis, modulating gut microbiota by decreasing harmful Enterococcus faecalis and Staphylococcus sciuri (67)

CYP3A4 inhibition by ketoconazole yielded an IC 50 of 0.83 M in iHLOs, comparable to HepaRG cells (0.42 M) but less potent than the IC 50 (0.056 M) from PHHs, demonstrating their applicability for studying CYP-mediated drug-drug interactions (Fig

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