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The initial symptoms of RA often include pain in the finger and wrist, while with the disease develops, it can affect large joints including the shoulder, knee and so on, resulting in joint mobility limited, joint deformity, and even disability

For all brain scans, the slices were positioned to run parallel to a line that joins the most infero-anterior and infero-posterior parts of the corpus callosum (ACPC line), covering the entire brain from the skull base to the vertex, with careful repositioning during the follow-up scan

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It plays a fundamental role in counterattacking the overproduction of reactive oxygen species (ROS) [1] that often occurs under cell injury conditions and that may lead, when uncontrolled, to the development of several types of diseases, including cancer [2]

doi: 10.3389/fnmol.2021.665686 66 MingX.JohnsonW

Human colonic organoid kit (K2003-HC, bioGenous) was used for human organoid growth medium