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Some investigators have suggested that the uremia of CKD is associated with decreased GH signalling contributing to the state of hepatic GH resistance (74) ( Figure 4 )

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Protein or zinc deficient diets can alter copper metabolism, so a malnourished individual might observe different outcomes than someone with adequate nutrition

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Like many peptide materials, GHK-Cu may demonstrate reduced stability in aqueous solution over time, particularly under conditions of elevated temperature or prolonged light exposure

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