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4 and Supplementary Table 13)

Single-target drugs often produce inconsistent results because biological systems are interconnected

ERS can activate the expression of Ca 2+ release channels on inositol 1,4,5-trisphosphate receptors (IP3R), thereby mediating the release of ER-Ca 2+

IRE1, inositol requiring enzyme-1

TGF-1, Transforming growth factor-1

All animal experiments were performed according to protocols approved by the Animal Care Committee of Shandong University (No
