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Superoxide can also combine with nitric oxide to generate peroxynitrite (ONOO ) which rapidly oxidizes biological macromolecules (Beckman and Koppenol, 2 and the disassembly of Fe-S clusters can disable nutrient oxidation and ATP production which has been implicated in the pathogenesis of non-alcoholic fatty liver disease, obesity, diabetes mellitus, and several neurological disorders (James et al., 2012)

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Effect of D 1 -like and D2-like receptor antagonists on methamphetamine and 3,4-methylenedioxymethamphetamine self-administration in rats