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doi: 10.1080/01443615.2019.1604644 253 ThakkerDRavalAPatelIWaliaR

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While traditional anti-diabetic medications are effective in improving cognition and memory, long-term use of these medications can be accompanied by undesirable side effects

Alpha4 integrins are type I cAMP-dependent protein kinase-anchoring proteins

It is difficult to judge for sure whether the early drastic decrease in Plp- and Mog- positive cells implies a drastic death/loss of the mature OLs or just an extreme-down regulation of the expression of these myelin-associated genes by the OLs while they themselves are still alive