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[DOI] [PubMed] [Google Scholar] 108.Reddy B, Jow T, Hantash BM

Severe calorie restriction in perimenopause can actually make things worse by: Further decreasing metabolic rate (adaptive thermogenesis) Increasing cortisol (chronic stress response) Promoting muscle loss over fat loss Disrupting already-irregular hormone patterns Ive seen women eating 1200 calories and doing intense cardio six days per week, completely exhausted and still gaining weight

Int J Cosmet Sci 2008;30:2716

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Localization of ammonia-metabolizing enzymes in human liver: ontogenesis of heterogeneity
