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Notably, autophagy dysfunction and metabolic disturbances form a vicious cycle - impaired autophagic flux exacerbates glucose and lipid metabolic imbalances (Kim and Lee, 2014), which may serve as a key driver for the progressive metabolic deterioration in DM (Figure 3)
Sun C et al
P., Sung I
There are two isotypes of GLS, which are encoded by two genes in mammals, renal type GLS1 and living type GLS2
However, this theory may be controversial
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