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10.1124/dmd.114.062034 Drug Metab
At the cellular level, vitamin B12 is involved in DNA synthesis and neuroprotection, acting as a cofactor for enzymes critical to these processes, such as methionine synthase and methylmalonyl-CoA mutase (, )
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These finding imply that targeting MAMs may hold promise as a therapeutic approach for the treatment of neuroinflammatory diseases
Many independent studies show the elevated levels of MDA, F2-Isoprostane, nitric oxide and diminished levels of reduced glutathione in patients with lupus nephritis [1417]
10.1186/s12906-020-03123-y 192
