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Nuzzo A, Maggiori L, Paugam-Burtz C, Cazals-Hatem D, Ronot M, Huguet A

[DOI] [PubMed] [Google Scholar] 92.Armstrong R.N

Germline mutations impair DNA mismatch repair, causing microsatellite instability and early-onset cancers in colorectal, endometrial, ovarian, and other organs

Upon exposure of HCC cells to specific ferroptosis inducers (e.g., Sorafenib, erastin, etc.), the expression of P62 increases and prevents the degradation of Nrf2 protein by competitively binding to Keap1 protein, and promotes the entry of Nrf2 into the nucleus [134], where nuclear Nrf2 can bind to transcriptional co-activators such as Maf protein and activate a series of downstream ferroptosis-related proteins, especially antioxidant proteins transcription, including NADH Dehydrogenase, Quinone 1 (NQO1), heme oxygenase-1 (HO-1), and FTH1 [135,136,137,138]

BMJ, 344 , e406

While a mild rash around this area can be normal, it could also be a sign of a serious allergic reaction if it gets worse or doesnt go away