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Indeed, there were notable differences in immune microenvironment composition, immune checkpoint gene expression, and chemotherapy response between the two risk groups (220)

Clinical outcomes of isolated lower extremity or foot burns in diabetic versus non-diabetic patients: a 10-year retrospective analysis

Sci Rep (2022) 12(1):20912

Through the catalytic action of PKM2, phosphoenolpyruvate is converted to pyruvate, which is the hub connecting glycolysis and oxidative phosphorylation, and inhibitors targeting PKM2 have become the focus of research

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This requires multiple daily doses that pose problems for dosing during school timings and can thus compromise patient compliance