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At the same time, in old treated animals, the dynamic of oxygen cost of myocardial work did not differ from the untreated group (Figure 4E) that might be due to compensatory mechanisms in myocardium developed with aging

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Blood serum APAP concentrations measured in these patients ranged from 4 to 284 mg/L (median 52 mg/L), and correlated positively with APAP signals measured with the HRMS-based method (r 2 = 0.89, table S7)