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It mostly does this in the liver, which is close to poisons and makes them easier to get rid of

Pre-clinical studies highlighted the efficacy of small molecule mimetics of BDNF, such as deoxygedunin and N-acetyl-serotonin, against AD neuropathology (Jang et al., 2010a, 2010b

Abstract Excessive consumption of the simple sugar fructose, which induces excessive hepatic lipogenesis and gut dysbiosis, is a risk factor for cardiometabolic diseases

doi: 10.1016/j.foodchem.2017.03.130 26

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The nerves do not have enough room to function correctly and they begin to cause pain, numbness and weakness