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In most human GST isozymes the amino acid acting as the proton acceptor is a tyrosine, the phenol function of which is itself deprotonated by a neighboring strongly basic amino acid residue

Conversely, when dietary methionine is increased homocysteine cycling decreases (16, 17)

In terms of hormonal regulation, vitamin D can also antagonize the proliferative effects of E and progesterone in uterine fibroid tissue

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Therefore, exploration of Kla and its regulatory sites could help identify additional safe and effective therapeutic targets for cancer treatment and provide new directions for combination therapies
