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FASEB J 30:12871299

In HCC driven by obesity and nonalcoholic steatohepatitis, the downregulation of CPT2 leads to the accumulation of acylcarnitines, among which C18:1-carnitine enhances spheroid formation by HCC cells through STAT3 activation, indicating that the accumulation of acylcarnitine can promote the development of liver cancer [212]

Type 1 and Type 2 diabetes mellitus: commonalities, differences and the importance of exercise and nutrition

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doi: 10.1002/ana.23665

Although clinical studies specifically addressing AX effects on the brain in obesity are still lacking, preclinical data indicate that AX is able to cross the bloodbrain barrier and accumulate in metabolically relevant brain regions, including the hippocampus [87]