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Such studies directly address whether mimetics can amplify training-induced adaptations or partially substitute for exercise when physical activity is limited

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J Biol Chem 281:32043209

Alam, J., Kim, Y

TM's efficacy has also been investigated in animal models of inflammatory and immune-related diseases (24, 25), but clinical studies are needed to evaluate whether copper depletion might stabilize diseases and improve survival in humans, as suggested by a trial of TM therapy with patients with biliary cirrhosis (26)