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A recent study reveals that CD36 + CAFs internalize Ox-LDL to trigger lipid peroxidation, subsequently secreting macrophage migration inhibitory factor (MIF) to recruit MDSCs, thereby establishing an immunosuppressive TME (Zhu 2023).In recurrent glioblastoma, NOX4-mediated endothelial ferroptosis is upregulated, yet its underlying mechanisms require further investigation (Liang et al

Acute alcohol consumption disrupts redox balance and causes cellular oxidative stress, which is indicated by markers such as MDA and CYP2E1

For example, sustained stimulation by inflammatory cytokines such as IL-1 and TNF-, persistent oxidative stress, and pathological iron overload states have all been shown to significantly suppress SLC7A11 expression or its transport activity (Xiao et al., 2024

As discussed earlier, PRDX6 binds GPX4 through a Cys47-mediated disulfide bond, facilitating GPX4 localization to cellular membranes and enhancing lipid peroxide detoxification 100

Vascular smooth muscle cells specific deletion of angiopoietin-like protein 8 prevents angiotensin II-promoted hypertension and cardiovascular hypertrophy

Lynch Syndrome Practice Bulletin