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8 The mechanisms of APAP-induced cell death, which apply to both animals and humans, include the formation of the reactive metabolite N-acetyl-p-benzoquinone imine (NAPQI) by cytochrome P450 2E1 (Cyp2E1), depletion of hepatic GSH, and protein adduct formation, primarily in mitochondria

It exerts a protective effect by scavenging peroxynitrite and preventing the release of AIF and EndoG from mitochondria and subsequent nuclear DNA breakage (Du et al., 2015)

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